| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DNER |
| Gene ID: | 92737 |
| Uniprot ID: | DNER_HUMAN |
| Immunogen Region: | 140-240 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-240 of human DNER (NP_620711.3). |
| Immunogen Sequence: | PATGWTESMAPRQLQPVPAT QEPDKILPRSQATVTLPTWQ PKTGQKVVEMKWDQVEVIPD IACGNASSNSSAGGRLVSFE VPQNTSVKIRQDATASLILL W |
| Tissue Specificity | Expressed in brain, spinal cord and adrenal gland. |
| Function | Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis. |
| Protein Name | Delta And Notch-Like Epidermal Growth Factor-Related Receptor |
| Database Links | Reactome: R-HSA-2122948 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPresent On The Membrane Of Dendrites And Cell Bodies But Excluded From Axonal MembraneAlso Found In Early Endosomes In The Somatodendritic Region |
| Alternative Antibody Names | Anti-Delta And Notch-Like Epidermal Growth Factor-Related Receptor antibodyAnti-DNER antibodyAnti-BET antibodyAnti-UNQ262 antibodyAnti-PRO299 antibody |
Information sourced from Uniprot.org