| Short Description : | Rabbit polyclonal anti-DNAL1 (2-40 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC/WB |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB (confirmed by recombinant protein). A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation: | Lyophilised |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | DNAL1 |
| Gene ID: | 83544 |
| Uniprot ID: | DNAL1_HUMAN |
| Immunogen: | A synthetic peptide from aa region 2-40 of human DNAL1 conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region: | 2-40 aa |
| Specificity: | Specific for DNAL1. |
| Function | Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency. Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme. Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry. |
| Protein Name | Dynein Axonemal Light Chain 1Lc1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCilium Axoneme |
| Alternative Antibody Names | Anti-Dynein Axonemal Light Chain 1 antibodyAnti-Lc1 antibodyAnti-DNAL1 antibodyAnti-C14orf168 antibody |
Information sourced from Uniprot.org
