| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DNAJC7 |
| Gene ID: | 7266 |
| Uniprot ID: | DNJC7_HUMAN |
| Immunogen Region: | 230-380 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-380 of human DNAJC7 (NP_003306.3). |
| Immunogen Sequence: | VQFFVQALRMAPDHEKACIA CRNAKALKAKKEDGNKAFKE GNYKLAYELYTEALGIDPNN IKTNAKLYCNRGTVNSKLRK LDDAIEDCTNAVKLDDTYIK AYLRRAQCYMDTEQYEEAVR DYEKVYQTEKTKEHKQLLKN AQLELKKSKRK |
| Function | Acts as a co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm. |
| Protein Name | Dnaj Homolog Subfamily C Member 7 Tetratricopeptide Repeat Protein 2 Tpr Repeat Protein 2 |
| Database Links | Reactome: R-HSA-3371453 |
| Cellular Localisation | Cytoplasm Nucleus Cytoskeleton Colocalizes With Nr1i3 To Microtubules |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily C Member 7 antibody Anti-Tetratricopeptide Repeat Protein 2 antibody Anti-Tpr Repeat Protein 2 antibody Anti-DNAJC7 antibody Anti-TPR2 antibody Anti-TTC2 antibody |
Information sourced from Uniprot.org