| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-DnaJ homolog subfamily A member 3, mitochondrial is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DNAJA3 |
| Gene ID: | 9093 |
| Uniprot ID: | DNJA3_HUMAN |
| Specificity: | This antibody detects endogenous levels of TID1 at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human TID1 |
| Post Translational Modifications | Tyrosine phosphorylated. |
| Function | Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C.in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. |
| Protein Name | Dnaj Homolog Subfamily A Member 3 - Mitochondrial Dnaj Protein Tid-1 Htid-1 Hepatocellular Carcinoma-Associated Antigen 57 Tumorous Imaginal Discs Protein Tid56 Homolog |
| Cellular Localisation | Mitochondrion Matrix Cytoplasm Cytosol Postsynaptic Cell Membrane Peripheral Membrane Protein Recruited To The Postsynaptic Cell Membrane Of The Neuromuscular Junction Through Interaction With Musk |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily A Member 3 - Mitochondrial antibody Anti-Dnaj Protein Tid-1 antibody Anti-Htid-1 antibody Anti-Hepatocellular Carcinoma-Associated Antigen 57 antibody Anti-Tumorous Imaginal Discs Protein Tid56 Homolog antibody Anti-DNAJA3 antibody Anti-HCA57 antibody Anti-TID1 antibody |
Information sourced from Uniprot.org