| Tissue Specificity | Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. |
| Post Translational Modifications | Tyrosine phosphorylated. |
| Function | Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C.in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. |
| Protein Name | Dnaj Homolog Subfamily A Member 3 - MitochondrialDnaj Protein Tid-1Htid-1Hepatocellular Carcinoma-Associated Antigen 57Tumorous Imaginal Discs Protein Tid56 Homolog |
| Cellular Localisation | Mitochondrion MatrixCytoplasmCytosolPostsynaptic Cell MembranePeripheral Membrane ProteinRecruited To The Postsynaptic Cell Membrane Of The Neuromuscular Junction Through Interaction With Musk |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily A Member 3 - Mitochondrial antibodyAnti-Dnaj Protein Tid-1 antibodyAnti-Htid-1 antibodyAnti-Hepatocellular Carcinoma-Associated Antigen 57 antibodyAnti-Tumorous Imaginal Discs Protein Tid56 Homolog antibodyAnti-DNAJA3 antibodyAnti-HCA57 antibodyAnti-TID1 antibody |
Information sourced from Uniprot.org
