Anti-DNA Ligase III/LIG3 antibody [SRM14492] (STJ11109222)

SKU:
STJ11109222
$163.53 - $719.67
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Applications:WB/IHC-P/ELISA
Host:Rabbit
Reactivity:Human/Mouse/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :SRM14492
Isotype:IgG
Conjugation:Unconjugated
Purification:Affinity purification
Dilution Range:WB, 1:1000-1:5000
IHC-P, 1:50-1:200
ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:LIG3
Gene ID:3980
Uniprot ID:DNLI3_HUMAN
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Tissue Specificity Testis, thymus, prostate and heart.
Function Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair.
Protein Name Dna Ligase 3
Dna Ligase Iii
Polydeoxyribonucleotide Synthase Atp 3
Database Links Reactome: R-HSA-110381
Reactome: R-HSA-5649702
Reactome: R-HSA-5685939
Reactome: R-HSA-5696397
Reactome: R-HSA-6782210
Reactome: R-HSA-9913635 P49916-1
Cellular Localisation Isoform 1: Mitochondrion
Contains An N-Terminal Mitochondrial Transit Peptide
Isoform 2: Mitochondrion
Isoform 3: Nucleus
Lacks The N-Terminal Mitochondrial Transit Peptide
Isoform 4: Nucleus
Alternative Antibody Names Anti-Dna Ligase 3 antibody
Anti-Dna Ligase Iii antibody
Anti-Polydeoxyribonucleotide Synthase Atp 3 antibody
Anti-LIG3 antibody

Information sourced from Uniprot.org

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