| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Dog/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-DMTF1-Isoform a (N-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 70kDa band observed in Human Lung and Testis lysates (calculated MW of 74.9kDa according to NP_001135798.1). Recommended concentration: 1-3µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | DMTF1 |
| Gene ID: | 9988 |
| Uniprot ID: | DMTF1_HUMAN |
| Immunogen Region: | N-Term |
| Accession Number: | NP_066968.3; NP_001135798.1 |
| Specificity: | This antibody is expected to recognize both reported isoform a (NP_066968.3) only. Reported variants represent identical protein: NP_066968.3, NP_001135799.1 |
| Immunogen Sequence: | CPQNEADEIDSEDS |
| Post Translational Modifications | Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-D2/CDK6 complexes and to a lesser extent by the cyclin-D1/CDK4 complex. |
| Function | Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest. Binds to the consensus sequence 5'-CCCGGTATGT-3'. Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1. |
| Protein Name | Cyclin-D-Binding Myb-Like Transcription Factor 1Hdmtf1Cyclin-D-Interacting Myb-Like Protein 1Hdmp1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Cyclin-D-Binding Myb-Like Transcription Factor 1 antibodyAnti-Hdmtf1 antibodyAnti-Cyclin-D-Interacting Myb-Like Protein 1 antibodyAnti-Hdmp1 antibodyAnti-DMTF1 antibodyAnti-DMP1 antibody |
Information sourced from Uniprot.org
