| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DMPK (350-590) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DMPK |
| Gene ID: |
1760 |
| Uniprot ID: |
DMPK_HUMAN |
| Immunogen Region: |
350-590 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 350-590 of human DMPK (NP_004400.4). |
| Immunogen Sequence: |
SVPPFTPDFEGATDTCNFDL VEDGLTAMVSGGGETLSDIR EGAPLGVHLPFVGYSYSCMA LRDSEVPGPTPMELEAEQLL EPHVQAPSLEPSVSPQDETA EVAVPAAVPAAEAEAEVTLR ELQEALEEEVLTRQSLSREM EAIRTDNQNFASQLREAEAR NRDLEAHVRQLQERMELLQA EGATAVTGVPSPRATDPPSH LDGPPAVAVGQCPLVGPGPM HRRHLLLPARVPRPGLSEA |
| Tissue Specificity | Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons. |
| Post Translational Modifications | Phosphorylated. Autophosphorylates. Phosphorylation by RAF1 may result in activation of DMPK. Proteolytic processing of the C-terminus may remove the transmembrane domain and release the kinase from membranes stimulating its activity. |
| Function | Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. |
| Protein Name | Myotonin-Protein KinaseMt-PkDm-KinaseDmkDm1 Protein KinaseDmpkMyotonic Dystrophy Protein Kinase |
| Database Links | Reactome: R-HSA-5578775 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinCytoplasmic SideNucleus Outer MembraneMitochondrion Outer MembraneSarcoplasmic Reticulum MembraneCell MembraneCytoplasmCytosolLocalizes To Sarcoplasmic Reticulum Membranes Of CardiomyocytesIsoform 1: Mitochondrion MembraneIsoform 3: Mitochondrion Membrane |
| Alternative Antibody Names | Anti-Myotonin-Protein Kinase antibodyAnti-Mt-Pk antibodyAnti-Dm-Kinase antibodyAnti-Dmk antibodyAnti-Dm1 Protein Kinase antibodyAnti-Dmpk antibodyAnti-Myotonic Dystrophy Protein Kinase antibodyAnti-DMPK antibodyAnti-DM1PK antibodyAnti-MDPK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
