Anti-DLL4 antibody (317-530) (STJ114809)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DLL4 (317-530) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DLL4 |
| Gene ID | 54567 |
| Uniprot ID | DLL4_HUMAN |
| Immunogen Region | 317-530 |
| Immunogen Sequence | TGVDCELELSECDSNPCRNG GSCKDQEDGYHCLCPPGYYG LHCEHSTLSCADSPCFNGGS CRERNQGANYACECPPNFTG SNCEKKVDRCTSNPCANGGQ CLNRGPSRMCRCRPGFTGTY CELHVSDCARNPCAHGGTCH DLENGLMCTCPAGFSGRRCE VRTSIDACASSPCFNRATCY TDLSTDTFVCNCPYGFVGSR CEFPVGLPPSFPWV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 317-530 of human DLL4 (NP_061947.1). |
Additional Info
| Tissue Specificity | Expressed in vascular endothelium. |
| Function | Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis.negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate. |
| Protein Name | Delta-Like Protein 4Drosophila Delta Homolog 4Delta4 |
| Database Links | Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2660826Reactome: R-HSA-2691232Reactome: R-HSA-2894862Reactome: R-HSA-2979096Reactome: R-HSA-9013507Reactome: R-HSA-9013700 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Delta-Like Protein 4 antibodyAnti-Drosophila Delta Homolog 4 antibodyAnti-Delta4 antibodyAnti-DLL4 antibodyAnti-UNQ1895 antibodyAnti-PRO4341 antibody |
Information sourced from Uniprot.org