| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DKK4 (19-224) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DKK4 |
| Gene ID: |
27121 |
| Uniprot ID: |
DKK4_HUMAN |
| Immunogen Region: |
19-224 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 19-224 of human DKK4 (NP_055235.1). |
| Immunogen Sequence: |
LVLDFNNIRSSADLHGARKG SQCLSDTDCNTRKFCLQPRD EKPFCATCRGLRRRCQRDAM CCPGTLCVNDVCTTMEDATP ILERQLDEQDGTHAEGTTGH PVQENQPKRKPSIKKSQGRK GQEGESCLRTFDCGPGLCCA RHFWTKICKPVLLEGQVCSR RGHKDTAQAPEIFQRCDCGP GLLCRSQLTSNRQHARLRVC QKIEKL |
| Tissue Specificity | Expressed in cerebellum, T-cells, esophagus and lung. |
| Post Translational Modifications | Appears to be not glycosylated. Can be proteolytically processed by a furin-like protease. |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| Protein Name | Dickkopf-Related Protein 4Dickkopf-4Dkk-4Hdkk-4 Cleaved Into - Dickkopf-Related Protein 4 Short Form |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3772470Reactome: R-HSA-5339717 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Dickkopf-Related Protein 4 antibodyAnti-Dickkopf-4 antibodyAnti-Dkk-4 antibodyAnti-Hdkk-4 Cleaved Into - Dickkopf-Related Protein 4 Short Form antibodyAnti-DKK4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
