| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DKK4 |
| Gene ID: | 27121 |
| Uniprot ID: | DKK4_HUMAN |
| Immunogen Region: | 19-224 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-224 of human DKK4 (NP_055235.1). |
| Immunogen Sequence: | LVLDFNNIRSSADLHGARKG SQCLSDTDCNTRKFCLQPRD EKPFCATCRGLRRRCQRDAM CCPGTLCVNDVCTTMEDATP ILERQLDEQDGTHAEGTTGH PVQENQPKRKPSIKKSQGRK GQEGESCLRTFDCGPGLCCA RHFWTKICKPVLLEGQVCSR RGHKDTAQAPEIFQRCDCGP GLLCRSQLTSNRQHARLRVC QKIEKL |
| Tissue Specificity | Expressed in cerebellum, T-cells, esophagus and lung. |
| Post Translational Modifications | Appears to be not glycosylated. Can be proteolytically processed by a furin-like protease. |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| Protein Name | Dickkopf-Related Protein 4 Dickkopf-4 Dkk-4 Hdkk-4 Cleaved Into - Dickkopf-Related Protein 4 Short Form |
| Database Links | Reactome: R-HSA-201681 Reactome: R-HSA-3772470 Reactome: R-HSA-5339717 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Dickkopf-Related Protein 4 antibody Anti-Dickkopf-4 antibody Anti-Dkk-4 antibody Anti-Hdkk-4 Cleaved Into - Dickkopf-Related Protein 4 Short Form antibody Anti-DKK4 antibody |
Information sourced from Uniprot.org
