| Tissue Specificity | Highest expression in heart, brain, and spinal cord. |
| Post Translational Modifications | N- and O-glycosylated. |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| Protein Name | Dickkopf-Related Protein 3Dickkopf-3Dkk-3Hdkk-3 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Dickkopf-Related Protein 3 antibodyAnti-Dickkopf-3 antibodyAnti-Dkk-3 antibodyAnti-Hdkk-3 antibodyAnti-DKK3 antibodyAnti-REIC antibodyAnti-UNQ258 antibodyAnti-PRO295 antibody |
Information sourced from Uniprot.org
