| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DISC1 |
| Gene ID: | 27185 |
| Uniprot ID: | DISC1_HUMAN |
| Immunogen Region: | 1-200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human DISC1 (NP_001158009.1). |
| Immunogen Sequence: | MPGGGPQGAPAAAGGGGVSH RAGSRDCLPPAACFRRRRLA RRPGYMRSSTGPGIGFLSPA VGTLFRFPGGVSGEESHHSE SRARQCGLDSRGLLVRSPVS KSAAAPTVTSVRGTSAHFGI QLRGGTRLPDRLSWPCGPGS AGWQQEFAAMDSSETLDASW EAACSDGARRVRAAGSLPSA ELSSNSCSPGCGPEVPPTPP |
| Tissue Specificity | Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter. |
| Post Translational Modifications | Ubiquitinated. Ubiquitination with 'Lys-48'-linked polyubiquitin chains leads to its proteasomal degradation. |
| Function | Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding. Plays a role, together with PCNT, in the microtubule network formation. |
| Protein Name | Disrupted In Schizophrenia 1 Protein |
| Cellular Localisation | Cytoplasm Cytoskeleton Mitochondrion Microtubule Organizing Center Centrosome Postsynaptic Density Colocalizes With Ndel1 In The Perinuclear Region And The Centrosome Localizes To Punctate Cytoplasmic Foci Which Overlap In Part With Mitochondria Colocalizes With Pcnt At The Centrosome |
| Alternative Antibody Names | Anti-Disrupted In Schizophrenia 1 Protein antibody Anti-DISC1 antibody Anti-KIAA0457 antibody |
Information sourced from Uniprot.org