| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DIAPH2 |
| Gene ID: | 1730 |
| Uniprot ID: | DIAP2_HUMAN |
| Immunogen Region: | 1-120 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human DIAPH2 (NP_009293.1). |
| Immunogen Sequence: | MEQPGAAASGAGGGSEEPGG GRSNKRSAGNRAANEEETKN KPKLNIQIKTLADDVRDRIT SFRKSTVKKEKPLIQHPIDS QVAMSEFPAAQPLYDERSLN LSEKEVLDLFEKMMEDMNLN |
| Tissue Specificity | Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes. |
| Function | Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. |
| Protein Name | Protein Diaphanous Homolog 2Diaphanous-Related Formin-2Drf2 |
| Database Links | Reactome: R-HSA-5663220Reactome: R-HSA-9013405 O60879-3Reactome: R-HSA-9035034 |
| Cellular Localisation | Isoform 3: CytoplasmCytosolEarly EndosomeIsoform 3 Is Cytosolic But When Coexpressed With RhodThe 2 Proteins Colocalize To Early Endosomes |
| Alternative Antibody Names | Anti-Protein Diaphanous Homolog 2 antibodyAnti-Diaphanous-Related Formin-2 antibodyAnti-Drf2 antibodyAnti-DIAPH2 antibodyAnti-DIA antibody |
Information sourced from Uniprot.org