Anti-DGUOK antibody (STJA0008552)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human dGK
General Information
| Short Description | Rabbit polyclonal anti-Deoxyguanosine kinase, mitochondrial for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DGUOK |
| Gene ID | 1716 |
| Uniprot ID | DGUOK_HUMAN |
| Immunogen | Synthesized peptide derived from human dGK |
| Specificity | This antibody detects endogenous levels of dGK at Human, Mouse |
Additional Info
| Function | Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents. |
| Protein Name | Deoxyguanosine Kinase - MitochondrialDeoxyadenosine Kinase - Mitochondrial |
| Database Links | Reactome: R-HSA-74217 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Deoxyguanosine Kinase - Mitochondrial antibodyAnti-Deoxyadenosine Kinase - Mitochondrial antibodyAnti-DGUOK antibodyAnti-DGK antibody |
Information sourced from Uniprot.org