| Function | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position. By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression. |
| Protein Name | Diacylglycerol Kinase IotaDag Kinase IotaDgk-Iota |
| Database Links | Reactome: R-HSA-114508 |
| Cellular Localisation | Cell ProjectionAxonDendritePresynapsePostsynapsePostsynaptic DensitySynaptic Cell MembraneCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneCytoplasmCytosolNucleusExcluded From Inhibitory SynapsesLocalization Between Cytoplasm And Nucleus Is Regulated By Protein Kinase CBoth In The Detergent Soluble And Particulate Fractions |
| Alternative Antibody Names | Anti-Diacylglycerol Kinase Iota antibodyAnti-Dag Kinase Iota antibodyAnti-Dgk-Iota antibodyAnti-DGKI antibody |
Information sourced from Uniprot.org
