| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
DGKG |
| Gene ID: |
1608 |
| Uniprot ID: |
DGKG_HUMAN |
| Immunogen Region: |
1-250 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human DGKG (NP_001074214.1). |
| Immunogen Sequence: |
MGEERWVSLTPEEFDQLQKY SEYSSKKIKDALTEFNEGGS LKQYDPHEPISYDVFKLFMR AYLEVDLPQPLSTHLFLAFS QKPRHETSDHPTEGASNSEA NSADTNIQNADNATKADEAC APDTESNMAEKQAPAEDQVA ATPLEPPVPRSSSSESPVVY LKDVVCYLSLLETGRPQDKL EFMFRLYDSDENGLLDQAEM DCIVNQMLHIAQYLEWDPTE LRPILKEMLQGMDYDRDGF |
| Tissue Specificity | Predominantly expressed in retina and in a much lesser extent in the brain. Other tissues contain extremely low levels of DGK-gamma. |
| Function | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Has no apparent specificity with regard to the acyl compositions of diacylglycerol. Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination. |
| Protein Name | Diacylglycerol Kinase GammaDag Kinase GammaDiglyceride Kinase GammaDgk-Gamma |
| Database Links | Reactome: R-HSA-114508 |
| Cellular Localisation | MembraneCytoplasmCytosolCytoskeleton |
| Alternative Antibody Names | Anti-Diacylglycerol Kinase Gamma antibodyAnti-Dag Kinase Gamma antibodyAnti-Diglyceride Kinase Gamma antibodyAnti-Dgk-Gamma antibodyAnti-DGKG antibodyAnti-DAGK3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
