| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DET1 (15-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DET1 |
| Gene ID: |
55070 |
| Uniprot ID: |
DET1_HUMAN |
| Immunogen Region: |
15-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 15-240 of human DET1 (NP_060466.2). |
| Immunogen Sequence: |
HVSTIKPRRIQNQNVIHRLE RRRISSGKAGTHWHQVRVFH QNVFPNFTVVNVEKPPCFLR KFSPDGRYFIAFSSDQTSLE IYEYQGCQAAEDLLQGYEGE ILSNGNDQRSVNIRGRLFER FFVLLHITNVAANGEHLNRE CSLFTDDCRCVIVGSAAYLP DEPHPPFFEVYRNSESVTPN PRSPLEDYSLHIIDLHTGRL CDTRTFKCDKVVLSHNQGLY LYKNIL |
| Tissue Specificity | Highly expressed in the ovary, some lymphoid organs and resting leukocytes. |
| Function | Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation. |
| Protein Name | Det1 HomologDe-Etiolated-1 Homolog |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Det1 Homolog antibodyAnti-De-Etiolated-1 Homolog antibodyAnti-DET1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
