| Host: | Goat |
| Applications: | Pep-ELISA/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-Desmoglein 1/DSG1 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000. WB: Preliminary experiments in lysates of cell lines A431, HeLa, K562 and MOLT4 gave no specific signal but low background (at antibody concentration up to 1µg/ml). IHC: In paraffin em |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | DSG1 |
| Gene ID: | 1828 |
| Uniprot ID: | DSG1_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_001933.2 |
| Immunogen Sequence: | YTTSDTLKPSVHVHD |
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. |
| Protein Name | Desmoglein-1 Cadherin Family Member 4 Desmosomal Glycoprotein 1 Dg1 Dgi Pemphigus Foliaceus Antigen |
| Database Links | Reactome: R-HSA-351906 Reactome: R-HSA-6798695 Reactome: R-HSA-6805567 Reactome: R-HSA-6809371 Reactome: R-HSA-9696264 Reactome: R-HSA-9696270 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Cell Junction Desmosome Cytoplasm Nucleus |
| Alternative Antibody Names | Anti-Desmoglein-1 antibody Anti-Cadherin Family Member 4 antibody Anti-Desmosomal Glycoprotein 1 antibody Anti-Dg1 antibody Anti-Dgi antibody Anti-Pemphigus Foliaceus Antigen antibody Anti-DSG1 antibody Anti-CDHF4 antibody |
Information sourced from Uniprot.org