| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S3MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DSC3 |
| Gene ID: | 1825 |
| Uniprot ID: | DSC3_HUMAN |
| Immunogen Region: | 797-896 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 797-896 of human Desmocollin 3 (Q14574). |
| Immunogen Sequence: | HHHTLDSCRGGHTEVDNCRY TYSEWHSFTQPRLGEKLHRC NQNEDRMPSQDYVLTYNYEG RGSPAGSVGCCSEKQEEDGL DFLNNLEPKFITLAEACTKR |
| Tissue Specificity | Epidermis, buccal mucosa, esophagus and cervix. |
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. |
| Protein Name | Desmocollin-3Cadherin Family Member 3Desmocollin-4Ht-Cp |
| Database Links | Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionDesmosome |
| Alternative Antibody Names | Anti-Desmocollin-3 antibodyAnti-Cadherin Family Member 3 antibodyAnti-Desmocollin-4 antibodyAnti-Ht-Cp antibodyAnti-DSC3 antibodyAnti-CDHF3 antibodyAnti-DSC4 antibody |
Information sourced from Uniprot.org