| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DENN domain-containing protein 1B (325-375 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DENND1B |
| Gene ID: |
163486 |
| Uniprot ID: |
DEN1B_HUMAN |
| Immunogen Region: |
325-375 aa |
| Specificity: |
This antibody detects endogenous levels of DEN1B at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human DEN1B at the amino acid range 325-375 |
| Post Translational Modifications | Phosphorylated on serine and/or threonine, possibly regulating the guanine nucleotide exchange factor (GEF) activity. |
| Function | Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Plays a role in clathrin-mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells. |
| Protein Name | Denn Domain-Containing Protein 1bConnecdenn 2Protein Fam31b |
| Database Links | Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmCytosolCytoplasmic VesicleClathrin-Coated Vesicle |
| Alternative Antibody Names | Anti-Denn Domain-Containing Protein 1b antibodyAnti-Connecdenn 2 antibodyAnti-Protein Fam31b antibodyAnti-DENND1B antibodyAnti-C1orf218 antibodyAnti-FAM31B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
