| Post Translational Modifications | Phosphorylated on serine and/or threonine, possibly regulating the guanine nucleotide exchange factor (GEF) activity. |
| Function | Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Plays a role in clathrin-mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells. |
| Protein Name | Denn Domain-Containing Protein 1bConnecdenn 2Protein Fam31b |
| Database Links | Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmCytosolCytoplasmic VesicleClathrin-Coated Vesicle |
| Alternative Antibody Names | Anti-Denn Domain-Containing Protein 1b antibodyAnti-Connecdenn 2 antibodyAnti-Protein Fam31b antibodyAnti-DENND1B antibodyAnti-C1orf218 antibodyAnti-FAM31B antibody |
Information sourced from Uniprot.org
