| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-DENN domain-containing protein 1A (14-64 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DENND1A |
| Gene ID: | 57706 |
| Uniprot ID: | DEN1A_HUMAN |
| Immunogen Region: | 14-64 aa |
| Specificity: | This antibody detects endogenous levels of DEN1A at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human DEN1A at the amino acid range 14-64 |
| Function | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes. Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P. |
| Protein Name | Denn Domain-Containing Protein 1aConnecdenn 1ConnecdennProtein Fam31a |
| Database Links | Reactome: R-HSA-8876198 |
| Cellular Localisation | Cytoplasmic VesicleClathrin-Coated Vesicle MembranePeripheral Membrane ProteinPresynaptic Cell MembraneAssociates To Membranes Via Lipid-Binding Activity |
| Alternative Antibody Names | Anti-Denn Domain-Containing Protein 1a antibodyAnti-Connecdenn 1 antibodyAnti-Connecdenn antibodyAnti-Protein Fam31a antibodyAnti-DENND1A antibodyAnti-FAM31A antibodyAnti-KIAA1608 antibody |
Information sourced from Uniprot.org