| Host: |
Rabbit |
| Applications: |
ELISA/IP/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Deformed Epidermal Autoregulatory Factor 1 (500-565) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Biotin |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.5-1.5 µg/µl |
| Dilution Range: |
WB: 1:500ELISA: 1:10, 000IP: 1:200IHC: 1:50-1:150ICC: 1:50-1:150 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Deaf1 |
| Gene ID: |
54006 |
| Uniprot ID: |
DEAF1_MOUSE |
| Immunogen Region: |
500-565 |
| Immunogen: |
Synthetic peptide taken within amino acid region 500-565 on mouse Deformed epidermal autoregulatory factor 1 homolog protein. |
| Tissue Specificity | Ubiquitously expressed during embryogenesis, with higher expression in regions of the central nervous system, dorsal root ganglia, submandibular gland, epidermis and breast. In 12-week-old NOD mice, expression of isoform 2 is sevenfold higher in lymph node stromal elements than in T-cells and tenfold higher than in B-cells. |
| Post Translational Modifications | May be phosphorylated by DNA-PK complex in a DNA independent manner (in vitro). |
| Function | Transcription factor that binds to sequence with multiple copies of 5'-TTCCGG-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 2. Isoform 2 may inhibit transcriptional activity of isoform 1 by interacting with it and retaining it in the cytoplasm. Transcriptional activator of EIF4G3. May also involved in behavior. |
| Protein Name | Deformed Epidermal Autoregulatory Factor 1 HomologNuclear Deaf-1-Related Transcriptional RegulatorNudr |
| Cellular Localisation | Isoform 1: NucleusCytoplasmIsoform 2: CytoplasmNucleusDisplays Some Nuclear Localization When Expressed With Isoform 1Suggesting That It May Heterodimerize With Isoform 1 And Shuttle To The Nucleus Using The Nuclear Localization Signal Of Isoform 1 |
| Alternative Antibody Names | Anti-Deformed Epidermal Autoregulatory Factor 1 Homolog antibodyAnti-Nuclear Deaf-1-Related Transcriptional Regulator antibodyAnti-Nudr antibodyAnti-Deaf1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
