STJ70871 (0. 3µg/ml) staining of Daudi (A) , Jurkat (B) and HepG2 (C) lysates (35µg protein in RIPA buffer). Detected by chemiluminescence.

Anti-DEAD-box protein 6 antibody (C-Term) (STJ70871)

SKU:
STJ70871-100
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Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human/Mouse/Rat/Dog
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Goat polyclonal antibody anti-DEAD-box protein 6 (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: Peptide ELISA: antibody detection limit dilution 1:128000.
WB: Approx 50kDa band observed in lysates of cell lines Daudi, Jurkat and HepG2 (calculated MW of 53.2kDa according to NP_004388.1). Recommended concentration: 0.3-1µg/ml. Primary incubat
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: DDX6
Gene ID: 1656
Uniprot ID: DDX6_HUMAN
Immunogen Region: C-Term
Accession Number: NP_004388.1
Immunogen Sequence: AEYHSEPVEDEKP
Post Translational Modifications Sumoylated.
Function Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
Protein Name Probable Atp-Dependent Rna Helicase Ddx6
Atp-Dependent Rna Helicase P54
Dead Box Protein 6
Oncogene Rck
Database Links Reactome: R-HSA-430039
Cellular Localisation Cytoplasm
P-Body
Nucleus
Cytoplasmic Ribonucleoprotein Granule
Imported In The Nucleus Via Interaction With Eif4enif1/4e-T Via A Piggy-Back Mechanism
Upon Cellular Stress
Relocalizes To Stress Granules
Alternative Antibody Names Anti-Probable Atp-Dependent Rna Helicase Ddx6 antibody
Anti-Atp-Dependent Rna Helicase P54 antibody
Anti-Dead Box Protein 6 antibody
Anti-Oncogene Rck antibody
Anti-DDX6 antibody
Anti-HLR2 antibody
Anti-RCK antibody

Information sourced from Uniprot.org

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