| Function | Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription.R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA. |
| Protein Name | Probable Atp-Dependent Rna Helicase Ddx23100 Kda U5 Snrnp-Specific ProteinDead Box Protein 23Prp28 HomologU5-100kd |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72165 |
| Cellular Localisation | NucleusChromosomeDuring TranscriptionAccumulates At Chromatin Loci Where Unscheduled R-Loops Form And Colocalizes With Paused 'Ser-5'-Phosphorylated Polr2a/Rna Polymerase Ii And Kinase Srpk2 |
| Alternative Antibody Names | Anti-Probable Atp-Dependent Rna Helicase Ddx23 antibodyAnti-100 Kda U5 Snrnp-Specific Protein antibodyAnti-Dead Box Protein 23 antibodyAnti-Prp28 Homolog antibodyAnti-U5-100kd antibodyAnti-DDX23 antibody |
Information sourced from Uniprot.org
