| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
DDHD2 |
| Gene ID: |
23259 |
| Uniprot ID: |
DDHD2_HUMAN |
| Immunogen Region: |
360-500 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 360-500 of human DDHD2 (NP_056029.2). |
| Immunogen Sequence: |
ILTNQKDSLGDIDSEKDSLN IVMDQGDTPTLEEDLKKLQL SEFFDIFEKEKVDKEALALC TDRDLQEIGIPLGPRKKILN YFSTRKNSMGIKRPAPQPAS GANIPKESEFCSSSNTRNGD YLDVGIGQVSVKYPRLIYKP E |
| Tissue Specificity | Widely expressed (at protein level). |
| Function | Diacylglycerol (DAG) and triacylglycerol (TAG) lipase required for proper lipid homeostasis in the central nervous system. It cooperates with PNPLA2/ATGL in neuronal TAG catabolism and hydrolyzes sn-1,3 DAG downstream of PNPLA2/ATGL. In vitro, it also acts as a phospholipase that hydrolyzes preferentially phosphatidic acids, including 1,2-dioleoyl-sn-phosphatidic acid, phosphatidylcholine and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane. |
| Protein Name | Triacylglycerol Hydrolase Ddhd2Tag HydrolaseDdhd Domain-Containing Protein 2Kiaa0725pPhospholipase Ddhd2Sam - Wwe And Ddhd Domain-Containing Protein 1Triglyceride Hydrolase Ddhd2Triglyceride Lipase |
| Database Links | Reactome: R-HSA-1483166 |
| Cellular Localisation | CytoplasmCytosolEndoplasmic Reticulum-Golgi Intermediate CompartmentGolgi ApparatusCis-Golgi NetworkCycles Between The Golgi Apparatus And The CytosolDdhd2 Recruitment To The Golgi/Endoplasmic Reticulum-Golgi Intermediate Compartment (Ergic) Is Regulated By The Levels Of PhosphoinositidesIncluding Pi(4)P |
| Alternative Antibody Names | Anti-Triacylglycerol Hydrolase Ddhd2 antibodyAnti-Tag Hydrolase antibodyAnti-Ddhd Domain-Containing Protein 2 antibodyAnti-Kiaa0725p antibodyAnti-Phospholipase Ddhd2 antibodyAnti-Sam - Wwe And Ddhd Domain-Containing Protein 1 antibodyAnti-Triglyceride Hydrolase Ddhd2 antibodyAnti-Triglyceride Lipase antibodyAnti-DDHD2 antibodyAnti-KIAA0725 antibodyAnti-SAMWD1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
