| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DCTN2 (50-320) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:20-1:50 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DCTN2 |
| Gene ID: |
10540 |
| Uniprot ID: |
DCTN2_HUMAN |
| Immunogen Region: |
50-320 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 50-320 of human DCTN2 (NP_006391.1). |
| Immunogen Sequence: |
HIIVNPNAAYDKFKDKRVGT KGLDFSDRIGKTKRTGYESG EYEMLGEGLGVKETPQQKYQ RLLHEVQELTTEVEKIKTTV KESATEEKLTPVLLAKQLAA LKQQLVASHLEKLLGPDAAI NLTDPDGALAKRLLLQLEAT KNSKGGSGGKTTGTPPDSSL VTYELHSRPEQDKFSQAAKV AELEKRLTELETAVRCDQDA QNPLSAGLQGACLMETVELL QAKVSALDLAVLDQVEARL |
| Function | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length. Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. |
| Protein Name | Dynactin Subunit 250 Kda Dynein-Associated PolypeptideDynactin Complex 50 Kda SubunitDctn-50P50 Dynamitin |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-2565942Reactome: R-HSA-3371497Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-6807878Reactome: R-HSA-6811436Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Dynactin Subunit 2 antibodyAnti-50 Kda Dynein-Associated Polypeptide antibodyAnti-Dynactin Complex 50 Kda Subunit antibodyAnti-Dctn-50 antibodyAnti-P50 Dynamitin antibodyAnti-DCTN2 antibodyAnti-DCTN50 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunofluorescence analysis of PC-12 cells using [KO Validated] KEAP1 Rabbit polyclonal antibody (STJ11104499) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/177143/368561/STJ11104499_1__57159.1713134043.jpg?c=1 "Immunofluorescence analysis of PC-12 cells using [KO Validated] KEAP1 Rabbit polyclonal antibody (STJ11104499) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")