Anti-DCTN2 antibody (280-401) (STJ117041)

Name: Anti-DCTN2 antibody (280-401) (STJ117041)
SKU: STJ117041
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ117041

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Short Description	Rabbit polyclonal DCTN2 (280-401) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	DCTN2
Gene ID	10540
Uniprot ID	DCTN2_HUMAN
Immunogen Region	280-401
Immunogen Sequence	VLDQVEARLQSVLGKVNEIA KHKASVEDADTQSKVHQLYE TIQRWSPIASTLPELVQRLV TIKQLHEQAMQFGQLLTHLD TTQQMIANSLKDNTTLLTQV QTTMRENLATVEGNFASIDE RM
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 280-401 of human DCTN2 (NP_006391.1).

Function	Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length. Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
Protein Name	Dynactin Subunit 2 50 Kda Dynein-Associated Polypeptide Dynactin Complex 50 Kda Subunit Dctn-50 P50 Dynamitin
Database Links	Reactome: R-HSA-2132295 Reactome: R-HSA-2565942 Reactome: R-HSA-3371497 Reactome: R-HSA-380259 Reactome: R-HSA-380270 Reactome: R-HSA-380284 Reactome: R-HSA-380320 Reactome: R-HSA-5620912 Reactome: R-HSA-6807878 Reactome: R-HSA-6811436 Reactome: R-HSA-8854518
Cellular Localisation	Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Membrane Peripheral Membrane Protein
Alternative Antibody Names	Anti-Dynactin Subunit 2 antibody Anti-50 Kda Dynein-Associated Polypeptide antibody Anti-Dynactin Complex 50 Kda Subunit antibody Anti-Dctn-50 antibody Anti-P50 Dynamitin antibody Anti-DCTN2 antibody Anti-DCTN50 antibody

Information sourced from Uniprot.org