| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DCTD |
| Gene ID: | 1635 |
| Uniprot ID: | DCTD_HUMAN |
| Immunogen Region: | 1-178 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-178 of human DCTD (NP_001912.2). |
| Immunogen Sequence: | MSEVSCKKRDDYLEWPEYFM AVAFLSAQRSKDPNSQVGAC IVNSENKIVGIGYNGMPNGC SDDVLPWRRTAENKLDTKYP YVCHAELNAIMNKNSTDVKG CSMYVALFPCNECAKLIIQA GIKEVIFMSDKYHDSDEATA ARLLFNMAGVTFRKFIPKCS KIVIDFDSINSRPSQKLQ |
| Function | Catalyzes the deamination of dCMP to dUMP, providing the nucleoside monophosphate substrate for the thymidylate synthase/TYMS. Also, part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the first step in that pathway, the deamination of 5-hydroxymethyl-dCMP (hmdCMP). |
| Protein Name | Deoxycytidylate DeaminaseDcmp Deaminase |
| Database Links | Reactome: R-HSA-499943 |
| Alternative Antibody Names | Anti-Deoxycytidylate Deaminase antibodyAnti-Dcmp Deaminase antibodyAnti-DCTD antibody |
Information sourced from Uniprot.org