| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DAPP1 |
| Gene ID: | 27071 |
| Uniprot ID: | DAPP1_HUMAN |
| Immunogen Region: | 100-273 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 100-273 of human DAPP1 (NP_055210.2). |
| Immunogen Sequence: | SSLKDFVKHFANQPLIGSET GTLMVLKHPYPRKVEEPSIY ESVRVHTAMQTGRTEDDLVP TAPSLGTKEGYLTKQGGLVK TWKTRWFTLHRNELKYFKDQ MSPEPIRILDLTECSAVQFD YSQERVNCFCLVFPFRTFYL CAKTGVEADEWIKILRWKLS QIRKQLNQGEGTIR |
| Tissue Specificity | Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells. |
| Post Translational Modifications | Phosphorylated on tyrosine residues. |
| Function | May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. |
| Protein Name | Dual Adapter For Phosphotyrosine And 3-Phosphotyrosine And 3-PhosphoinositideHdapp1B Lymphocyte Adapter Protein Bam32B-Cell Adapter Molecule Of 32 Kda |
| Database Links | Reactome: R-HSA-983695 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinMembrane-Associated After Cell Stimulation Leading To Its Translocation |
| Alternative Antibody Names | Anti-Dual Adapter For Phosphotyrosine And 3-Phosphotyrosine And 3-Phosphoinositide antibodyAnti-Hdapp1 antibodyAnti-B Lymphocyte Adapter Protein Bam32 antibodyAnti-B-Cell Adapter Molecule Of 32 Kda antibodyAnti-DAPP1 antibodyAnti-BAM32 antibodyAnti-HSPC066 antibody |
Information sourced from Uniprot.org