Anti-Cytokeratin 8 antibody [SM5164] (STJA0005164)

Anti-Cytokeratin 8 antibody [SM5164] (STJA0005164)

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STJA0005164-50
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Short Description :Mouse monoclonal anti-Cytokeratin 8 for use in IHC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:IHC/IF
Host:Mouse
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :SM5164
Conjugation:Unconjugated
Purification:The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Dilution Range:IHC/IF (H) 1:200-1:500
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instruction:Store at-20C for up to one year, and avoid repeated freeze-thaw cycles.
Gene Symbol:KRT8
Gene ID:3856
Uniprot ID:K2C8_HUMAN
Immunogen:Synthesized peptide derived from human Cytokeratin 8
Post Translational Modifications Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization. O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
Function Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Protein Name Keratin - Type Ii Cytoskeletal 8
Cytokeratin-8
Ck-8
Keratin-8
K8
Type-Ii Keratin Kb8
Database Links Reactome: R-HSA-6805567
Reactome: R-HSA-6809371
Cellular Localisation Cytoplasm
Nucleus
Nucleoplasm
Nucleus Matrix
Alternative Antibody Names Anti-Keratin - Type Ii Cytoskeletal 8 antibody
Anti-Cytokeratin-8 antibody
Anti-Ck-8 antibody
Anti-Keratin-8 antibody
Anti-K8 antibody
Anti-Type-Ii Keratin Kb8 antibody
Anti-KRT8 antibody
Anti-CYK8 antibody

Information sourced from Uniprot.org

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