| Host: | Mouse |
| Applications: | IHC-F/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Cytokeratin 8 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 2A4 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | PBS with 1% BSA & 0.1% sodium azide |
| Concentration: | 100 ug/mL |
| Dilution Range: | IHC-F WB 1:1000 |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Gene Symbol: | KRT8 |
| Gene ID: | 3856 |
| Uniprot ID: | K2C8_HUMAN |
| Immunogen: | Cytokeratins isolated from cultured pig kidney epithelial cells |
| Tissue Specificity | Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. |
| Post Translational Modifications | Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization. O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. |
| Function | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. |
| Protein Name | Keratin - Type Ii Cytoskeletal 8 Cytokeratin-8 Ck-8 Keratin-8 K8 Type-Ii Keratin Kb8 |
| Database Links | Reactome: R-HSA-6805567 Reactome: R-HSA-6809371 |
| Cellular Localisation | Cytoplasm Nucleus Nucleoplasm Nucleus Matrix |
| Alternative Antibody Names | Anti-Keratin - Type Ii Cytoskeletal 8 antibody Anti-Cytokeratin-8 antibody Anti-Ck-8 antibody Anti-Keratin-8 antibody Anti-K8 antibody Anti-Type-Ii Keratin Kb8 antibody Anti-KRT8 antibody Anti-CYK8 antibody |
Information sourced from Uniprot.org