| Host: | Mouse |
| Applications: | WB/IHC/IF |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Cytochrome C is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Monoclonal |
| Clone ID : | SM5173 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% sodium azide, 100 Mu g/ml BSA and 50% glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB (M, R) 1:500-1:1000IHC/IF (H, R) 1:500-1:1000/1:250-1:1000 |
| Storage Instruction: | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
| Gene Symbol: | Cycs |
| Gene ID: | 13063 |
| Uniprot ID: | CYC_MOUSE |
| Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Cytochrome c |
| Post Translational Modifications | Binds 1 heme c group covalently per subunit. Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration. |
| Function | Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. |
| Protein Name | Cytochrome C - Somatic |
| Database Links | Reactome: R-MMU-111457Reactome: -MMU-111458Reactome: -MMU-111459Reactome: -MMU-2151201Reactome: -MMU-3299685Reactome: -MMU-5620971Reactome: -MMU-5628897Reactome: -MMU-611105Reactome: -MMU-9627069Reactome: -MMU-9707564 |
| Cellular Localisation | Mitochondrion Intermembrane SpaceLoosely Associated With The Inner Membrane |
| Alternative Antibody Names | Anti-Cytochrome C - Somatic antibodyAnti-Cycs antibody |
Information sourced from Uniprot.org