| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CYR61 (120-220) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CCN1 |
| Gene ID: |
3491 |
| Uniprot ID: |
CCN1_HUMAN |
| Immunogen Region: |
120-220 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 120-220 of human CYR61 (NP_001545.2). |
| Immunogen Sequence: |
QCTCIDGAVGCIPLCPQELS LPNLGCPNPRLVKVTGQCCE EWVCDEDSIKDPMEDQDGLL GKELGFDASEVELTRNNELI AVGKGSSLKRLPVFGMEPRI L |
| Function | Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. |
| Protein Name | Ccn Family Member 1Cellular Communication Network Factor 1Cysteine-Rich Angiogenic Inducer 61Insulin-Like Growth Factor-Binding Protein 10Ibp-10Igf-Binding Protein 10Igfbp-10Protein Cyr61Protein Gig1 |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Ccn Family Member 1 antibodyAnti-Cellular Communication Network Factor 1 antibodyAnti-Cysteine-Rich Angiogenic Inducer 61 antibodyAnti-Insulin-Like Growth Factor-Binding Protein 10 antibodyAnti-Ibp-10 antibodyAnti-Igf-Binding Protein 10 antibodyAnti-Igfbp-10 antibodyAnti-Protein Cyr61 antibodyAnti-Protein Gig1 antibodyAnti-CCN1 antibodyAnti-CYR61 antibodyAnti-GIG1 antibodyAnti-IGFBP10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
