Anti-CYP4V2 antibody (206-525) (STJ28656)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CYP4V2 (206-525) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CYP4V2 |
| Gene ID | 285440 |
| Uniprot ID | CP4V2_HUMAN |
| Immunogen Region | 206-525 |
| Immunogen Sequence | ICETAMGKNIGAQSNDDSEY VRAVYRMSEMIFRRIKMPWL WLDLWYLMFKEGWEHKKSLQ ILHTFTNSVIAERANEMNAN EDCRGDGRGSAPSKNKRRAF LDLLLSVTDDEGNRLSHEDI REEVDTFMFEGHDTTAAAIN WSLYLLGSNPEVQKKVDHEL DDVFGKSDRPATVEDLKKLR YLECVIKETLRLFPSVPLFA RSVSEDCEVAGYRVLKGTEA VIIPYALHRDPRYFPNPEE |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human CYP4V2 (NP_997235.3). |
Additional Info
| Tissue Specificity | Broadly expressed. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium (RPE) and lymphocytes. |
| Function | A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs. Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate (C14>C12>C16). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). |
| Protein Name | Cytochrome P450 4v2Docosahexaenoic Acid Omega-Hydroxylase Cyp4v2Long-Chain Fatty Acid Omega-Monooxygenase |
| Database Links | Reactome: R-HSA-211976Reactome: R-HSA-2453902 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cytochrome P450 4v2 antibodyAnti-Docosahexaenoic Acid Omega-Hydroxylase Cyp4v2 antibodyAnti-Long-Chain Fatty Acid Omega-Monooxygenase antibodyAnti-CYP4V2 antibody |
Information sourced from Uniprot.org