| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cytochrome P450 4f11 (60-130) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP4F11 |
| Gene ID: |
57834 |
| Uniprot ID: |
CP4FB_HUMAN |
| Immunogen Region: |
60-130 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 60-130 of human CYP4F11 (NP_001122404.1). |
| Immunogen Sequence: |
FWGHQGLVTPTEEGMKTLTQ LVTTYPQGFKLWLGPTFPLL ILCHPDIIRPITSASAAVAP KDMIFYGFLKP |
| Tissue Specificity | Expressed mainly in human liver, followed by kidney, heart, and skeletal muscle. |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). Catalyzes with high efficiency the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3-hydroxydicarboxylic acids. Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation. Metabolizes with low efficiciency fatty acids, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) and its oxygenated metabolite 8-hydroxyeicosatetraenoic acid (8-HETE). Catalyzes N- and O-demethylation of drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine, imipramine and verapamil. |
| Protein Name | Cytochrome P450 4f11Cypivf113-Hydroxy Fatty Acids Omega-Hydroxylase Cyp4f11Docosahexaenoic Acid Omega-HydroxylaseLong-Chain Fatty Acid Omega-MonooxygenasePhylloquinone Omega-Hydroxylase Cyp4f11 |
| Database Links | Reactome: R-HSA-211935Reactome: R-HSA-211958Reactome: R-HSA-211979Reactome: R-HSA-2142691 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 4f11 antibodyAnti-Cypivf11 antibodyAnti-3-Hydroxy Fatty Acids Omega-Hydroxylase Cyp4f11 antibodyAnti-Docosahexaenoic Acid Omega-Hydroxylase antibodyAnti-Long-Chain Fatty Acid Omega-Monooxygenase antibodyAnti-Phylloquinone Omega-Hydroxylase Cyp4f11 antibodyAnti-CYP4F11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
