| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CYP3A7 (244-503) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP3A7 |
| Gene ID: |
100861540/1551 |
| Uniprot ID: |
CP3A7_HUMAN |
| Immunogen Region: |
244-503 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 244-503 of human CYP3A7 (NP_000756.3). |
| Immunogen Sequence: |
KVISFLTKSVKQIKEGRLKE TQKHRVDFLQLMIDSQNSKD SETHKALSDLELMAQSIIFI FAGYETTSSVLSFIIYELAT HPDVQQKVQKEIDTVLPNKA PPTYDTVLQLEYLDMVVNET LRLFPVAMRLERVCKKDVEI NGMFIPKGVVVMIPSYVLHH DPKYWTEPEKFLPERFSKKN KDNIDPYIYTPFGSGPRNCI GMRFALVNMKLALVRVLQNF SFKPCKETQIPLKLRFGGL |
| Tissue Specificity | Expressed in fetal liver (at protein level). |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position. Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development. Also involved in the oxidative metabolism of xenobiotics including anticonvulsants. |
| Protein Name | Cytochrome P450 3a7Cypiiia7Cytochrome P450-HflaP450hlp2 |
| Database Links | Reactome: R-HSA-211981 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 3a7 antibodyAnti-Cypiiia7 antibodyAnti-Cytochrome P450-Hfla antibodyAnti-P450hlp2 antibodyAnti-CYP3A7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
