| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CYP2C18 |
| Gene ID: | 1562 |
| Uniprot ID: | CP2CI_HUMAN |
| Immunogen Region: | 231-490 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 231-490 of human CYP2C18 (NP_000763.1). |
| Immunogen Sequence: | NKIAENFAYIKSYVLERIKE HQESLDMNSARDFIDCFLIK MEQEKHNQQSEFTVESLIAT VTDMFGAGTETTSTTLRYGL LLLLKYPEVTAKVQEEIECV VGRNRSPCMQDRSHMPYTDA VVHEIQRYIDLLPTNLPHAV TCDVKFKNYLIPKGTTIITS LTSVLHNDKEFPNPEMFDPG HFLDKSGNFKKSDYFMPFSA GKRMCMGEGLARMELFLFLT TILQNFNLKSQVDPKDIDI |
| Function | A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). |
| Protein Name | Cytochrome P450 2c18Cypiic18Cytochrome P450-6b/29c |
| Database Links | Reactome: R-HSA-211981 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 2c18 antibodyAnti-Cypiic18 antibodyAnti-Cytochrome P450-6b/29c antibodyAnti-CYP2C18 antibody |
Information sourced from Uniprot.org