Anti-CYFIP1 antibody (1-270) (STJ112329)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CYFIP1 (1-270) antibody for use in WB, IP and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CYFIP1 |
| Gene ID | 23191 |
| Uniprot ID | CYFP1_HUMAN |
| Immunogen Region | 1-270 |
| Immunogen Sequence | MAAQVTLEDALSNVDLLEEL PLPDQQPCIEPPPSSLLYQP NFNTNFEDRNAFVTGIARYI EQATVHSSMNEMLEEGQEYA VMLYTWRSCSRAIPQVKCNE QPNRVEIYEKTVEVLEPEVT KLMNFMYFQRNAIERFCGEV RRLCHAERRKDFVSEAYLIT LGKFINMFAVLDELKNMKCS VKNDHSAYKRAAQFLRKMAD PQSIQESQNLSMFLANHNKI TQSLQQQLEVISGYEELLA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human CYFIP1 (NP_055423.1). |
Additional Info
| Function | Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. May act as an invasion suppressor in cancers. |
| Protein Name | Cytoplasmic Fmr1-Interacting Protein 1Specifically Rac1-Associated Protein 1Sra-1P140sra-1 |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-4420097Reactome: R-HSA-5663213Reactome: R-HSA-6798695Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-9013423Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmPerinuclear RegionCell ProjectionLamellipodiumRuffleSynapseSynaptosomeHighly Expressed In The Perinuclear RegionEnriched In SynaptosomesAlso Enriched In Membrane Ruffles And At The Tips Of Lamellipodia |
| Alternative Antibody Names | Anti-Cytoplasmic Fmr1-Interacting Protein 1 antibodyAnti-Specifically Rac1-Associated Protein 1 antibodyAnti-Sra-1 antibodyAnti-P140sra-1 antibodyAnti-CYFIP1 antibodyAnti-KIAA0068 antibody |
Information sourced from Uniprot.org