| Host: | Mouse |
| Applications: | IHC-P |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Cyclin D1 (200-295aa) is suitable for use in Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | ZM178 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a/Kappa |
| Formulation: | Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin |
| Purification: | Affinity purified |
| Dilution Range: | 1:100-200 |
| Storage Instruction: | Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C. |
| Gene Symbol: | CCNDBP1 |
| Gene ID: | 23582 |
| Uniprot ID: | CCDB1_HUMAN |
| Immunogen Region: | 200-295aa |
| Specificity: | Positive control: Mantle cell lymphoma |
| Immunogen: | Synthetic peptide corresponding to residues within aa 200-295 of Cyclin D1 |
| Tissue Specificity | Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas. |
| Post Translational Modifications | Phosphorylated. |
| Function | May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription. |
| Protein Name | Cyclin-D1-Binding Protein 1Grap2 And Cyclin-D-Interacting ProteinHuman Homolog Of Maid |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cyclin-D1-Binding Protein 1 antibodyAnti-Grap2 And Cyclin-D-Interacting Protein antibodyAnti-Human Homolog Of Maid antibodyAnti-CCNDBP1 antibodyAnti-DIP1 antibodyAnti-GCIP antibodyAnti-HHM antibody |
Information sourced from Uniprot.org