| Post Translational Modifications | Autoubiquitinated by the CUL9-RBX1 complex at Lys-87. Neddylated. Neddylation is mediated by E1 enzyme UBA3-NAE1 complex and E2 enzyme UBE2F. Structural rearrangment of the C-terminal TRIAD/RBR supradomain may play a role in neddylation and deneddylation. |
| Function | Core component of a Cul9-RING ubiquitin-protein ligase complex composed of CUL9 and RBX1. The CUL9-RBX1 complex mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits the ubiquitination of BIRC5. The CUL9-RBX1 complex also mediates mono-ubiquitination of p53/TP53. Acts as a cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and its subsequent function. Ubiquitinates apurinic/apyrimidinic endodeoxyribonuclease APEX2. Ubiquitination by the CUL9-RBX1 complex is predominantly mediated by E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2D2. |
| Protein Name | Cullin-9Cul-9Ubch7-Associated Protein 1P53-Associated Parkin-Like Cytoplasmic Protein |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Cullin-9 antibodyAnti-Cul-9 antibodyAnti-Ubch7-Associated Protein 1 antibodyAnti-P53-Associated Parkin-Like Cytoplasmic Protein antibodyAnti-CUL9 antibodyAnti-H7AP1 antibodyAnti-KIAA0708 antibodyAnti-PARC antibody |
Information sourced from Uniprot.org
