Anti-CSNK2B antibody (Internal) (STJ73447)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-CSNK2B (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 26kDa band observed in lysates of cell lines NIH3T3, HeLa, K562, MCF7 and HepG2 (calculated MW of 24.9kDa according to NP_001311.3). Approx 25kDa band observed in Mouse Testis, |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CSNK2B |
| Gene ID | 1460 |
| Uniprot ID | CSK2B_HUMAN |
| Accession Number | NP_001311.3; NP_001269314.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | TGLNEQVPHYRQ |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_001311.3; NP_001269314.1). |
Additional Info
| Function | Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling. (Microbial infection) Upon infection with Epstein-Barr virus (EBV), the interaction with viral EBNA1 increases the association of CK2 with PML proteins, which increases PML phosphorylation by CK2, triggering the polyubiquitylation and degradation of PML. Seems to also suppress EBV reactivation by mediating ARK2N and JUN at the Z promoter which inhibits BZLF1 transcrition. |
| Protein Name | Casein Kinase Ii Subunit BetaCk Ii BetaPhosvitinProtein G5a |
| Database Links | Reactome: R-HSA-1483191Reactome: R-HSA-201688Reactome: R-HSA-2514853Reactome: R-HSA-445144Reactome: R-HSA-6798695Reactome: R-HSA-6804756Reactome: R-HSA-6814122Reactome: R-HSA-8934903Reactome: R-HSA-8939243Reactome: R-HSA-8948751Reactome: R-HSA-9755511Reactome: R-HSA-9828806 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Casein Kinase Ii Subunit Beta antibodyAnti-Ck Ii Beta antibodyAnti-Phosvitin antibodyAnti-Protein G5a antibodyAnti-CSNK2B antibodyAnti-CK2N antibodyAnti-G5A antibody |
Information sourced from Uniprot.org