| Tissue Specificity | Expressed in neural tissues, muscle and kidney. Expressed in the inner ear. |
| Function | Catalyzes the NAD(P)H-dependent reduction of imine double bonds of a number of cyclic ketimine substrates, including sulfur-containing cyclic ketimines. Under physiological conditions, it efficiently catalyzes delta(1)-piperideine-2-carboxylate (P2C) and delta(1)-pyrroline-2-carboxylate (Pyr2C) reduction, suggesting a central role in lysine and glutamate metabolism. Additional substrates are delta(2)-thiazoline-2-carboxylate (T2C), 3,4-dehydrothiomorpholine-3-carboxylate (AECK), and (R)-lanthionine ketimine (LK) that is reduced at very low rate compared to other substrates. Also catalyzes the NAD(P)H-dependent reduction of (S)-cystathionine ketimine (CysK). |
| Protein Name | Ketimine Reductase Mu-Crystallin1-Piperideine-2-Carboxylate/1-Pyrroline-2-Carboxylate ReductaseP2c/Pyr2c ReductaseNadp-Regulated Thyroid-Hormone-Binding Protein |
| Database Links | Reactome: R-HSA-71064 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ketimine Reductase Mu-Crystallin antibodyAnti-1-Piperideine-2-Carboxylate/1-Pyrroline-2-Carboxylate Reductase antibodyAnti-P2c/Pyr2c Reductase antibodyAnti-Nadp-Regulated Thyroid-Hormone-Binding Protein antibodyAnti-CRYM antibodyAnti-THBP antibody |
Information sourced from Uniprot.org
