| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CRYM |
| Gene ID: | 1428 |
| Uniprot ID: | CRYM_HUMAN |
| Immunogen Region: | 1-314 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-314 of human CRYM (NP_001879.1). |
| Immunogen Sequence: | MSRVPAFLSAAEVEEHLRSS SLLIPPLETALANFSSGPEG GVMQPVRTVVPVTKHRGYLG VMPAYSAAEDALTTKLVTFY EDRGITSVVPSHQATVLLFE PSNGTLLAVMDGNVITAKRT AAVSAIATKFLKPPSSEVLC ILGAGVQAYSHYEIFTEQFS FKEVRIWNRTKENAEKFADT VQGEVRVCSSVQEAVAGADV IITVTLATEPILFGEWVKPG AHINAVGASRPDWRELDDE |
| Tissue Specificity | Expressed in neural tissue, muscle and kidney. |
| Function | Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors. |
| Protein Name | Ketimine Reductase Mu-CrystallinNadp-Regulated Thyroid-Hormone-Binding Protein |
| Database Links | Reactome: R-HSA-71064 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ketimine Reductase Mu-Crystallin antibodyAnti-Nadp-Regulated Thyroid-Hormone-Binding Protein antibodyAnti-CRYM antibodyAnti-THBP antibody |
Information sourced from Uniprot.org