| Function | Cytidylyltransferase required for protein O-linked mannosylation. Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate. CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively. Not Involved in dolichol production. |
| Protein Name | D-Ribitol-5-Phosphate Cytidylyltransferase2-C-Methyl-D-Erythritol 4-Phosphate Cytidylyltransferase-Like ProteinIsoprenoid Synthase Domain-Containing ProteinHispd |
| Database Links | |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-D-Ribitol-5-Phosphate Cytidylyltransferase antibodyAnti-2-C-Methyl-D-Erythritol 4-Phosphate Cytidylyltransferase-Like Protein antibodyAnti-Isoprenoid Synthase Domain-Containing Protein antibodyAnti-Hispd antibodyAnti-CRPPA antibodyAnti-ISPD antibody |
Information sourced from Uniprot.org
