| Short Description : | Rabbit polyclonal CRLF2 (23-231) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:200-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CRLF2 |
| Gene ID: | 64109 |
| Uniprot ID: | CRLF2_HUMAN |
| Immunogen Region: | 23-231 |
| Immunogen Sequence: | QGGAAEGVQIQIIYFNLETV QVTWNASKYSRTNLTFHYRF NGDEAYDQCTNYLLQEGHTS GCLLDAEQRDDILYFSIRNG THPVFTASRWMVYYLKPSSP KHVRFSWHQDAVTVTCSDLS YGDLLYEVQYRSPFDTEWQS KQENTCNVTIEGLDAEKCYS FWVRVKAMEDVYGPDTYPSD WSEVTCWQRGEIRDACAETP TPPKPKLSK |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-231 of human CRLF2 (NP_071431.2). |
| Tissue Specificity | Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells. |
| Function | Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. |
| Protein Name | Cytokine Receptor-Like Factor 2Cytokine Receptor-Like 2Il-XrThymic Stromal Lymphopoietin Protein ReceptorTslp Receptor |
| Database Links | Reactome: R-HSA-1266695 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Cytokine Receptor-Like Factor 2 antibodyAnti-Cytokine Receptor-Like 2 antibodyAnti-Il-Xr antibodyAnti-Thymic Stromal Lymphopoietin Protein Receptor antibodyAnti-Tslp Receptor antibodyAnti-CRLF2 antibodyAnti-CRL2 antibodyAnti-ILXR antibodyAnti-TSLPR antibody |
Information sourced from Uniprot.org
