![Anti-CRIPTO antibody [3A6] (STJ97967)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/120116/229644/STJ97967_2_ELISA__62848.1602854457.jpg?c=1 "Anti-CRIPTO antibody [3A6] (STJ97967)")
![Anti-CRIPTO antibody [3A6] (STJ97967)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/120116/229644/STJ97967_2_ELISA__62848.1602854457.jpg?c=1 "Anti-CRIPTO antibody [3A6] (STJ97967)")
| Host: | Mouse |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Protein Cripto is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 3A6 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CRIPTO |
| Gene ID: | 6997 |
| Uniprot ID: | TDGF1_HUMAN |
| Specificity: | Cripto Monoclonal Antibody detects endogenous levels of Cripto protein. |
| Immunogen: | Purified recombinant fragment of human Cripto expressed in E. Coli. |
| Post Translational Modifications | The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, it is processed by GPI processing phospholipase A2 (TMEM8A), removing an acyl-chain at the sn-2 position of GPI and releasing CRIPTO as a lysophosphatidylinositol-bearing form, which is further cleaved by phospholipase D (GPLD1) into a soluble form. |
| Function | GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by TMEM8A modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. |
| Protein Name | Protein Cripto Cripto - Egf-Cfc Family Member Cripto-1 Growth Factor Crgf Epidermal Growth Factor-Like Cripto Protein Cr1 Teratocarcinoma-Derived Growth Factor 1 |
| Database Links | Reactome: R-HSA-1181150 Reactome: R-HSA-1433617 Reactome: R-HSA-2892247 |
| Cellular Localisation | Cell Membrane Lipid-Anchor Gpi-Anchor Secreted Released From The Cell Membrane By Gpi Cleavage |
| Alternative Antibody Names | Anti-Protein Cripto antibody Anti-Cripto - Egf-Cfc Family Member antibody Anti-Cripto-1 Growth Factor antibody Anti-Crgf antibody Anti-Epidermal Growth Factor-Like Cripto Protein Cr1 antibody Anti-Teratocarcinoma-Derived Growth Factor 1 antibody Anti-CRIPTO antibody Anti-CRIPTO-1 antibody Anti-TDGF1 antibody |
Information sourced from Uniprot.org