Anti-CRHR1 antibody (24-120) (STJ110707)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CRHR1 (24-120) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CRHR1 |
| Gene ID | 1394 |
| Uniprot ID | CRFR1_HUMAN |
| Immunogen Region | 24-120 |
| Immunogen Sequence | SLQDQHCESLSLASNISGLQ CNASVDLIGTCWPRSPAGQL VVRPCPAFFYGVRYNTTNNG YRECLANGSWAARVNYSECQ EILNEEKKSKVHYHVAV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 24-120 of human CRHR1 (NP_001138618.1). |
Additional Info
| Tissue Specificity | Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe. |
| Post Translational Modifications | C-terminal Ser or Thr residues may be phosphorylated. Phosphorylation at Ser-301 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling. |
| Function | G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. |
| Protein Name | Corticotropin-Releasing Factor Receptor 1Crf-R-1Crf-R1Crfr-1Corticotropin-Releasing Hormone Receptor 1Crh-R-1Crh-R1 |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndosomeAgonist-Binding Promotes Endocytosis |
| Alternative Antibody Names | Anti-Corticotropin-Releasing Factor Receptor 1 antibodyAnti-Crf-R-1 antibodyAnti-Crf-R1 antibodyAnti-Crfr-1 antibodyAnti-Corticotropin-Releasing Hormone Receptor 1 antibodyAnti-Crh-R-1 antibodyAnti-Crh-R1 antibodyAnti-CRHR1 antibodyAnti-CRFR antibodyAnti-CRFR1 antibodyAnti-CRHR antibody |
Information sourced from Uniprot.org