Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | CRHR1 |
Gene ID: | 104909134/1394 |
Uniprot ID: | CRFR1_HUMAN |
Immunogen Region: | 24-120 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-120 of human CRHR1 (NP_001138618.1). |
Immunogen Sequence: | SLQDQHCESLSLASNISGLQ CNASVDLIGTCWPRSPAGQL VVRPCPAFFYGVRYNTTNNG YRECLANGSWAARVNYSECQ EILNEEKKSKVHYHVAV |
Tissue Specificity | Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe. |
Post Translational Modifications | C-terminal Ser or Thr residues may be phosphorylated. Phosphorylation at Ser-301 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling. |
Function | G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. |
Protein Name | Corticotropin-Releasing Factor Receptor 1 Crf-R-1 Crf-R1 Crfr-1 Corticotropin-Releasing Hormone Receptor 1 Crh-R-1 Crh-R1 |
Database Links | Reactome: R-HSA-373080 Reactome: R-HSA-418555 |
Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Endosome Agonist-Binding Promotes Endocytosis |
Alternative Antibody Names | Anti-Corticotropin-Releasing Factor Receptor 1 antibody Anti-Crf-R-1 antibody Anti-Crf-R1 antibody Anti-Crfr-1 antibody Anti-Corticotropin-Releasing Hormone Receptor 1 antibody Anti-Crh-R-1 antibody Anti-Crh-R1 antibody Anti-CRHR1 antibody Anti-CRFR antibody Anti-CRFR1 antibody Anti-CRHR antibody |
Information sourced from Uniprot.org