| Tissue Specificity | Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. |
| Post Translational Modifications | Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome. Stimulated by phosphorylation. Phosphorylated on Ser-116 by TSSK4 in vitro. |
| Function | Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation. Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. |
| Protein Name | Camp-Responsive Element ModulatorInducible Camp Early RepressorIcer |
| Database Links | Reactome: R-HSA-400253 Q03060-6 |
| Cellular Localisation | NucleusIsoform 6: Cytoplasm |
| Alternative Antibody Names | Anti-Camp-Responsive Element Modulator antibodyAnti-Inducible Camp Early Repressor antibodyAnti-Icer antibodyAnti-CREM antibody |
Information sourced from Uniprot.org
