| Post Translational Modifications | Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response. Phosphorylated by CHUK/IKKA at Ser-1383 and Ser-1387.these phosphorylations promote cell growth by switching the binding preference of CREBBP from TP53 to NF-kappa-B. Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX. Autoacetylation is required for binding to protein substrates, such as acetylated histones and acetylated TP53/p53. Autoacetylation is induced by glucose and fatty acids. |
| Function | Acetylates histones, giving a specific tag for transcriptional activation. Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers. Acetylates PCNA.acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region. Acetylates DDX21, thereby inhibiting DDX21 helicase activity. Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation. Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway. |
| Protein Name | Histone Lysine Acetyltransferase CrebbpProtein Lactyltransferas CrebbpProtein-Lysine Acetyltransferase Crebbp |
| Cellular Localisation | CytoplasmNucleusRecruited To Nuclear Bodies By Ss18l1/CrestIn The Presence Of Alx1 Relocalizes From The Cytoplasm To The Nucleus |
| Alternative Antibody Names | Anti-Histone Lysine Acetyltransferase Crebbp antibodyAnti-Protein Lactyltransferas Crebbp antibodyAnti-Protein-Lysine Acetyltransferase Crebbp antibodyAnti-Crebbp antibodyAnti-Cbp antibody |
Information sourced from Uniprot.org
